Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects

Onaldo G. Rodrigues; Gilmar T. de Araújo; Hercília M. L. Rolim; Silene C. Nascimento; Luana C. B. B. Coelho

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Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects

Onaldo G. Rodrigues, Gilmar T. de Araújo, Hercília M. L. Rolim, Silene C. Nascimento, Luana C. B. B. Coelho

Resumo

In Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension.

Palavras-chave

Imunoparvum; hipersensitividade; câncer; fenol; adjuvante

Texto completo:

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Revista Ciências Exatas e Naturais - RECEN. Universidade Estadual do Centro-Oeste - UNICENTRO/PR, BRASIL.

Licenciada sob uma Licença Creative Common

ISSN 2175-5620 ON LINE; 1518-0352 IMPRESSO

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Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects

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